From Nic Marks, Salisbury, Wiltshire, UK
I have been a classic middle-class microdoser when it comes to the weight-loss drug Wegovy. For nine months, I took 0.5 milligrams a week (instead of the recommended maintenance dose of 2.4 mg) and lost over 20 kilograms. It was amazing. However, I became increasingly grumpy, so I decided to stop for a while. Ten days later, I was sitting reading when I felt a strange sensation; it was as if the lights had gone back on. My mood completely lifted. At lunch, my wife said it was the first time she had heard a lilt in my voice for months. I have been off Wegovy for over two months and have put on only 2 kg, and my mood is back to normal. It has definitely been a net positive for me, but the short and long-term side effects, including mood, need better investigation.(29 March, p 33)
