91av

Health

Targeted therapies exploit tiny chinks in cancer's armour

By Linda Geddes

7 October 2009

91av. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

Breast cancer cells are open to attack

(Image: Steve Gschmeissner/SPL)

THE weakness in Achilles’ heel didn’t pose much of a problem until it came into contact with Paris’s arrow – at which point it killed him. Now a range of tumours are meeting a similar fate thanks to drugs that turn otherwise insignificant gaps in their defences into fatal flaws.

A pioneering therapy that exploits such weaknesses is allowing women with late-stage, drug-resistant breast and ovarian tumours to survive for longer. More recent discoveries of similar genetic weaknesses in a range of other cancers are opening up the promise of…

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