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Life

Synthetic biology: Rewriting the code for life

By Linda Geddes

11 June 2008

91av. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

IT IS one of the fundamental principles of life. DNA makes RNA, and each three-letter “codon” of RNA is an instruction to include one of 20 different amino acids in a protein chain.

Not for much longer. Last week, Farren Isaacs from Harvard University announced that he was close to “recoding” the genome of Escherichia coli so that a DNA codon that usually signals the end of a protein chain now sits unused and waiting to be reassigned to a different amino acid – perhaps one that doesn’t even exist yet.

Meanwhile, Jason Chin at the University of Cambridge has modified…

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