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8 October 2025

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2WXCRCE Illustration of the components of proteolysis-targeting chimera (PROTAC) and some targeted protein degradation technologies. Seen are the proteolysis-targeting chimera molecule (left), an E3 ligase (green, middle) with a protein of interest (blue, middle) and ubiquitin (orange, middle), and a proteasome (blue/green, right).

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