91av

Health

Flu viruses have evolved proteins that let them break through mucus

Computer simulations of how influenza A moves through human mucus found it is ideally configured to slide through the sticky stuff on its way to infecting cells

By Karmela Padavic-Callaghan

28 October 2024

Proteins on the outside of influenza A viruses are key to breaching our bodies’ mucus barriers

Kateryna Kon/Science Photo Library/Alamy

Before viruses can infect cells, they must first get to them, often by traversing layers of the body’s protective mucus. Understanding how evolution optimised the influenza A virus for this slimy task could help us create new antiviral drugs.

If you just dropped an influenza A virus into mucus, natural diffusion would never carry it to cells fast enough to cause an infection, says at the University of California, Berkeley. Influenza A viruses – the only influenza…

Sign up to our weekly newsletter

Receive a weekly dose of discovery in your inbox! We'll also keep you up to date with 91av events and special offers.

Sign up

To continue reading, today with our introductory offers

or

Existing subscribers

Sign in to your account
Piano Exit Overlay Banner Mobile Piano Exit Overlay Banner Desktop